OncoTrace™ p40 (QR020) – Recombinant Antibody for Differential Diagnosis in Squamous Cell Carcinomas
High Specificity in the Diagnosis of Lung and Cervical Carcinomas
OncoTrace™ p40 (Clone QR020) is a recombinant rabbit monoclonal antibody (IgG), developed for the nuclear detection of the ΔNp63 isoform (p40) in FFPE tissues. Outperforming traditional p63, OncoTrace™ p40 offers equivalent sensitivity and significantly higher specificity, making it an essential tool in differentiating between squamous cell carcinoma (SqCC) and lung adenocarcinoma.
Why choose OncoTrace™ p40?
- Differential marker: p40 is a reference in distinguishing between squamous cell carcinoma and lung adenocarcinoma.
- Greater Specificity: Studies show that p40 outperforms p63 in diagnostic accuracy in squamous cell carcinoma.
- Recombinant Production: Eliminates variations in hybridomas, guaranteeing absolute consistency between batches.
- Wide application: Indicated for squamous cell carcinomas of the lung and cervix.
- Compatible with Automation: Validated for manual protocols and automated IHQ systems.
- Cruelty Free: Produced in vitro, without the need for animals.
Diagnostic Applications
OncoTrace™ p40 is indicated for the identification of squamous cell carcinomas, assisting pathologists in differentiating adenocarcinoma from pulmonary SqCC and in the diagnosis of cervical tumors. It should be read by specialists, taking into account the patient’s clinical context.
Comparison: Recombinant vs. hybridoma
| Features | OncoTrace™ Recombinant | Traditional hybridoma |
|---|---|---|
| Origin | Produced in vitro (without animals) | Produced in mice |
| Reliability | Identical performance between batches | Frequent variation |
| Specificity | High affinity, minimal background | Risk of cross-reactivity |
| Standardization | Fully controlled | Subject to genetic drift |
Technical Specifications
- Clone: QR020
- Host: Rabbit (IgG)
- Immunogen: Synthetic peptide of the human protein p40 (ΔNp63)
- Application: Immunohistochemistry (IHC) on FFPE tissues
- Cellular Location: Nuclear
- Recommended dilution (Concentrate): 1:100 – 1:200
- Positive Control: Squamous cell carcinoma of the lung
- Available volumes:
- Concentrate: 0.1 ml, 0.5 ml, 1 ml
- Ready for use: 3 ml, 7 ml, 15 ml
- Storage: 2°C – 8°C (stable until expiration date)
Frequently Asked Questions (FAQ)
What is the OncoTrace™ p40 antibody used for?
It is used to differentiate squamous cell carcinomas from adenocarcinomas, especially in the lungs and cervix, with greater specificity than p63.
What are the advantages of the recombinant format?
The recombinant format guarantees high standardization, batch-to-batch consistency and reliable results, reducing laboratory validation time.
Is the product compatible with automation?
Yes. OncoTrace™ p40 is validated for use on automated platforms and manual IHQ protocols.
How to store it?
Keep between 2°C and 8°C. Product stable until expiration date, even after opening.
Confidence for Differential Diagnoses
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