OncoTrace™ PAX8 (QR016) – Recombinant Antibody for the Diagnosis of Renal, Ovarian, Endometrial and Thyroid Tumors
High Specificity in Tumors of Müllerian, Renal and Thyroid Origin
OncoTrace™ PAX8 (Clone QR016) is a recombinant rabbit monoclonal antibody (IgG), developed for the nuclear detection of the PAX8 protein in FFPE tissues. PAX8 belongs to the Paired Box family of transcription factors and is essential in the embryonic development of kidneys, Müllerian organs and the thyroid. Its restricted expression makes it a highly sensitive and specific marker for tumors originating in these tissues.
Why choose the OncoTrace™ PAX8?
- Critical Marker: PAX8 is present in ovarian (71-99%), thyroid (~90%), endometrial (84-98%) and renal carcinoma (~90%) carcinomas.
- High Specificity: Excellent for distinguishing gynecological and renal tumors from metastatic neoplasms from other sites.
- Recombinant Production: Stable performance, no variation between batches.
- Compatible with Automation: Validated in manual protocols and automated IHQ platforms.
- Cruelty Free: Produced in vitro, without the use of animals.
Diagnostic Applications
OncoTrace™ PAX8 is indicated for the evaluation of tumors of Müllerian, renal and thyroid origin, helping to differentiate primary carcinomas of these organs from metastases. It is an essential marker in diagnostic panels for ovarian, endometrial and renal tumors.
Comparison: Recombinant vs. hybridoma
| Features | OncoTrace™ Recombinant | Traditional hybridoma |
|---|---|---|
| Origin | Produced in vitro (without animals) | Produced in mice |
| Reliability | Identical performance between batches | Frequent variation |
| Specificity | High affinity, minimal background | Higher risk of cross-reactivity |
| Standardization | Fully controlled | Subject to genetic drift |
Technical Specifications
- Clone: QR016
- Host: Rabbit (IgG)
- Immunogen: Synthetic peptide of the human protein PAX8
- Application: Immunohistochemistry (IHC) on FFPE tissues
- Cellular Location: Nuclear
- Recommended dilution (Concentrate): 1:100 – 1:200
- Positive Control: Kidney (renal tubules), fallopian tube, endometrium or ovarian carcinoma
- Available volumes:
- Concentrate: 0.1 ml, 1 ml
- Ready for use: 1 ml, 6 ml
- Storage: 2°C – 8°C (stable until expiration date)
Frequently Asked Questions (FAQ)
What is the OncoTrace™ PAX8 antibody used for?
It is used to identify tumors of Müllerian, renal and thyroid origin, differentiating them from metastases from other sites.
What are the advantages of the recombinant format?
The recombinant format guarantees standardization, high reproducibility and elimination of the variations typical of hybridomas.
Is the product compatible with automation?
Yes. OncoTrace™ PAX8 is validated for use on automated IHQ platforms and in manual protocols.
How to store it?
Keep between 2°C and 8°C. Product stable until expiry date even after opening.
Confidence in High Complexity Diagnostics
Ensure precision and reliability in cancer diagnostics with recombinant technology. Request your quote or sample of OncoTrace™ PAX8 (QR016) now.
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