OncoTrace™ PLAP (QR084) – Recombinant Antibody for the Diagnosis of Germ Cell Tumors
Accuracy of PLAP Detection in Trophoblastic and Germ Tumors
OncoTrace™ PLAP (Clone QR084) is a recombinant rabbit monoclonal antibody (IgG) developed for the detection of Placental Alkaline Phosphatase (PLAP) in FFPE tissues. This biomarker is essential in the identification of germ cell tumors and in the evaluation of gestational trophoblastic diseases, as well as showing reactivity in somatic neoplasms such as breast, prostate, gastrointestinal and urinary tract cancers.
Why choose OncoTrace™ PLAP?
- Essential marker: PLAP is widely used to differentiate germ cell tumors from other neoplasms.
- Diagnostic Versatility: Useful in the evaluation of gestational trophoblastic disease and selected somatic tumors.
- High Specificity: Provides clear cytoplasmic and membrane staining in positive tissues.
- Recombinant Production: Guarantees consistent results, eliminating variations in traditional hybridomas.
- Universal compatibility: Validated for manual protocols and automated IHQ platforms.
- Cruelty Free: In vitro production without the use of animals.
Diagnostic Applications
OncoTrace™ PLAP assists pathologists in identifying germ cell and trophoblastic tumors, and has applications in breast, gastrointestinal tract, prostate and bladder carcinomas. Its interpretation must be carried out by specialists, always in the clinical context of the patient.
Comparison: Recombinant vs. hybridoma
| Features | OncoTrace™ Recombinant | Traditional hybridoma |
|---|---|---|
| Origin | Produced in vitro (without animals) | Produced in mice |
| Reliability | Identical performance between batches | Frequent variation |
| Specificity | High affinity, minimal background | Risk of cross-reactivity |
| Standardization | Fully controlled | Subject to genetic drift |
Technical Specifications
- Clone: QR084
- Host: Rabbit (IgG)
- Immunogen: Synthetic human protein peptide PLAP
- Application: Immunohistochemistry (IHC) on FFPE tissues
- Cellular Location: Cytoplasmic and membranous
- Recommended dilution (Concentrate): 1:100 – 1:200
- Positive Control: Placenta or germ cell tumor
- Available volumes:
- Concentrate: 0.1 ml, 1 ml
- Ready for use: 1ml, 6ml
- Storage: 2°C – 8°C (stable until expiration date)
Frequently Asked Questions (FAQ)
What is the OncoTrace™ PLAP antibody used for?
It is used to detect germ cell tumors and gestational trophoblastic diseases, as well as helping with differential diagnosis in somatic cancers.
What are the advantages of the recombinant format?
The recombinant format ensures maximum standardization and consistency between batches, reducing failures and optimizing laboratory validations.
Is the product compatible with automation?
Yes. OncoTrace™ PLAP is validated for both automated platforms and manual IHQ protocols.
How to store it?
Keep between 2°C and 8°C. Product stable until expiry date even after opening.
Reliability for High-Complexity Oncological Diagnostics
Invest in recombinant technology for diagnostic precision. Request a quote or order your sample of OncoTrace™ PLAP (QR084) now.
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